Endocrine Abstracts

Background: In the last decade, immunotherapy proved to be the frontline in the fight against cancer in a rocketing area of cancer types. Boosting the body’s inherent immune system, a new set of toxicities raised, labeled as immune-related adverse events (irAEs). Endocrine disorders, particularly thyroid dysfunctions, are by far the most frequent irAEs during immune checkpoint inhibitors (ICIs) therapy. New research data explored their predictive impact in cancer patients...

Introduction: Primary hyperparathyroidism is a condition in which one or more parathyroid glands have a pathological secretion of parathyroid hormone due to their abnormal function. Secondary hyperparathyroidism has normal parathyroid glands, but an abnormal secretion of PTH because of an underlying condition that influence their activity. It is important to differentiate between primary and secondary hyperparathyroidism because of the different treatment.<p class="abstext...

A 39 years old pacient presented for the first time in may 2023 with altered vision, dizziness, tachycardia and palpitations with paraclinical investigations suggestive for inappropiate TSH secretion: TSH=5.31 μUI/ml (NR: 0.27-0.42), fT4=56.8 pmol/l (NR: 11.9-21.6), fT3=17.4 ng/dl (NR: 3.1-6.8), ATPO <9 UI/ml, ATG=12.7 UI/ml (NR: 0-115). He has been treated with antithyroid drugs (Thiamazole 10 mg per day). The thyroid ultrasound and ophthalmological exam were normal....

Introduction: Pituitary adenomas are the most common pituitary tumours, but in 18% of cases we can find other rare tumours like: Rathke’s cleft cyst, craniopharingyomas, chordomas, meningiomas, infiltrative or infectious disease. Meningeal melanocytoma is a benign neoplasm of central nervous system, commonly located in the base of the brain, cerebellopontine angle and the pineal body, difficult to differentiate from a nonfunctional p...

Introduction: Pituitary adenomas are the most common pituitary tumours, but in 18% of cases we can find other rare tumours like: Rathke’s cleft cyst, craniopharingyomas, chordomas, meningiomas, infiltrative or infectious disease. Meningeal melanocytoma is a benign neoplasm of central nervous system, commonly located in the base of the brain, cerebellopontine angle and the pineal body, difficult to differentiate from a nonfunctional p...

Background: Differentiated thyroid cancer (DTC) encompases a wide spectrum of disease from clinically insignificant micro-tumors to aggressive cancers. The molecular signature can be used to predict tumor behaviour, and the co-existence of BRAF and TERT promoter mutations has been identified as a marker of adverse prognosis, but we have yet no available molecular data for the Romanian population.Objectives: To determine the prevalence of BRAF V600E and T...

Introduction: Bilateral pheochromocytomas (PHEOs) most often occur as components of hereditary syndromes: MEN2A, VHL disease or neurofibromatosis. The best surgical technique in such cases is yet disputed between cortical sparing or total adrenalectomy. Two important complications are related to each surgical technique: adrenal insufficiency (AI) or recurrence-which one is more harmful for the patient?Aim: To evaluate the complications (recurrence, AI) r...

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder caused by germline mutations of MEN1 gene, without genotype–phenotype correlation. It is defined as the occurrence of two or more primary neuroendocrine tumors (parathyroid, enteropancreatic, pituitary), or the occurrence of one of the MEN1-associated tumors in family members of a patient with a clinical diagnosis of MEN1. Multiple parathyroid tumors with hyperparathyroidism are the most common m...

Introduction: Pheochromocytomas (PHEOs) are tumors arising from medulla chromaffin cells. Their diagnosis is challenging due to a large clinical spectrum – from classical crisis to completely asymptomatic. Approximately 5.0–6.5% of adrenal incidentalomas are pheochromocytomas, and 8% of pheochromocytomas are completely asymptomatic, usually in a familial form.Aim: To compare biochemical and imagistic features of symptomatic/asymptomatic PHEOs.<...

Introduction: Hyperglycaemia occurs frequently in catecholamine-secreting tumours due to insulin suppression or induced insulin resistance. These changes can be reversible postoperatory (postOp).Objective: Our study aims to establish the impact of surgery in patients with catecholamine-secreting tumours upon glucose metabolism disorders, as well as the predictive factors for postOp diabetes-free patients.Methods: We retrospectively...